' 
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
Methotrexate reduces epidural fibrosis
Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway.
Moderate relevance due to indirect effects
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Read More
Most Useful Reviews
9.5
Deficiency solved!
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
Read More
8.3
Leg pain improvement
I experienced severe discomfort in my legs, but after taking Methylfolate, those painful attacks have ceased. I hope they don’t return when I stop taking it.
Read More
8.3
Painful leg condition
After taking Methylfolate, the intense pain I had in my legs has vanished. I’m relieved, but I hope these sensations do not return after stopping the vitamin.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
9
Methotrexate reduces epidural fibrosis
Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway.
Moderate relevance due to indirect effects
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.6
9.5
Energy restoration
Finally, I've regained my energy, and my heartbeats and feelings of suffocation have greatly improved.
9.5
Great back pain solution
I switched from folic acid because it aggravated my back pain. Now, I take this product every other day, and I feel fantastic!
9.5
Deficiency solved!
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
Read More
8.8
Back pain relief
This supplement is one of the best for addressing my folic acid deficiency. I take a pill daily, and it has alleviated my back pain.
8.3
Leg pain improvement
I experienced severe discomfort in my legs, but after taking Methylfolate, those painful attacks have ceased. I hope they don’t return when I stop taking it.
