5/6/2025
Last update
5/6/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Most Useful Reviews
9
Deficiency solved!
34 people found this helpful
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
9
Leg pain improvement
3 people found this helpful
I experienced severe discomfort in my legs, but after taking Methylfolate, those painful attacks have ceased. I hope they don’t return when I stop taking it.
9
Painful leg condition
1 people found this helpful
After taking Methylfolate, the intense pain I had in my legs has vanished. I’m relieved, but I hope these sensations do not return after stopping the vitamin.
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Deficiency solved!
34 people found this helpful
After finding out about a potential Vitamin B deficiency, I started taking Methyl Folate and a Super B Complex. Within three days, the painful numbness I had been experiencing was gone, and my blood count returned to normal after four weeks. I believe adjusting my diet alongside these supplements has improved my overall health, including reducing any back pain I had.
9
Leg pain improvement
3 people found this helpful
I experienced severe discomfort in my legs, but after taking Methylfolate, those painful attacks have ceased. I hope they don’t return when I stop taking it.
9
Painful leg condition
1 people found this helpful
After taking Methylfolate, the intense pain I had in my legs has vanished. I’m relieved, but I hope these sensations do not return after stopping the vitamin.
7.5
Back pain relief
1 people found this helpful
This supplement is one of the best for addressing my folic acid deficiency. I take a pill daily, and it has alleviated my back pain.
9
Energy restoration
1 people found this helpful
Finally, I've regained my energy, and my heartbeats and feelings of suffocation have greatly improved.
Frequently Asked Questions
9
Great back pain solution
1 people found this helpful
I switched from folic acid because it aggravated my back pain. Now, I take this product every other day, and I feel fantastic!
7.5
Back pain relief
1 people found this helpful
This supplement is one of the best for addressing my folic acid deficiency. I take a pill daily, and it has alleviated my back pain.
9
Leg pain improvement
3 people found this helpful
I experienced severe discomfort in my legs, but after taking Methylfolate, those painful attacks have ceased. I hope they don’t return when I stop taking it.
9
Painful leg condition
1 people found this helpful
After taking Methylfolate, the intense pain I had in my legs has vanished. I’m relieved, but I hope these sensations do not return after stopping the vitamin.
9
Energy restoration
1 people found this helpful
Finally, I've regained my energy, and my heartbeats and feelings of suffocation have greatly improved.
2
Side effects uncertainty
I encountered muscle pain and some palpitations after taking it. I'm unsure if it works, as I haven't taken it regularly due to side effects.
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
References
- Chen H, Yan L, Wang J, Sun Y, Li X, et al. Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. Eur J Pharmacol. 2017;796:131. 10.1016/j.ejphar.2016.12.032
